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基本情報
| 氏名 |
信久 幾夫 |
| 氏名（カナ） |
ﾉﾌﾞﾋｻ ｲｸｵ |
| 氏名（英語） |
NOBUHISA IKUO |
| 所属 |
中村学園大学 栄養科学部 栄養科学科 |
| 職名 |
教授 |
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- Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment 共著 Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T,… Miyakawa T. 2024/03
- A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo. 共著 Melig G, Nobuhisa I, Saito K, Tsukahara R, Itabashi A, Kanai Y, Kanai-Azuma M, Osawa M, Oshima M, Iwama A, Taga T 2023/08
- Glioma cells remotely promote erythropoiesis as a self-expanding strategy of cancer stem cells Aimaitijiang A
Tabu K
Wang W
Nobuhisa I
Taga T Genes Cells 2022-01
- Sry-related High Mobility Group Box 17 functions as a tumor suppressor by antagonizing the Wnt pathway Anani M
Nobuhisa I
Taga T Journal of Cancer Prevention 2020-12
- Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos Takahashi S
Nobuhisa I
Saito K
Melig G
Itabashi A
Harada K
Osawa M
Endo AT
Iwama A
Taga T Differentiation 2020-09
- Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis/Kiyoka Saito
Ikuo Nobuhisa
Kaho Harada
Satomi Takahashi
Maha Anani
Heiko Lickert
Masami Kanai-Azuma
Yoshiakira Kanai
Tetsuya Taga/Experimental Cell Research
- Thrombopoietin contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region/Kaho Harada
Ikuo Nobuhisa
Maha Anani
Kiyoka Saito
Tetsuya Taga/CYTOKINE
- A Synthetic Polymer Scaffold Reveals the Self-Maintenance Strategies of Rat Glioma Stem Cells by Organization of the Advantageous Niche/Kouichi Tabu
Nozomi Muramatsu
Christian Mangani
Mei Wu
Rong Zhang
Taichi Kimura
Kazuo Terashima
Norihisa Bizen
Ryosuke Kimura
Wenqian Wang
Yoshitaka Murota
Yasuhiro Kokubu
Ikuo Nobuhisa
Tetsushi Kagawa
Issay Kitabayashi
Mark Bradley
Tetsuya Taga/STEM CELLS
- Induction of protumoral CD11c(high) macrophages by glioma cancer stem cells through GM-CSF/Yasuhiro Kokubu
Kouichi Tabu
Nozomi Muramatsu
Wenqian Wang
Yoshitaka Murota
Ikuo Nobuhisa
Masahisa Jinushi
Tetsuya Taga/GENES TO CELLS
- Sox17 as a candidate regulator of myeloid restricted differentiation potential/Maha Anani
Ikuo Nobuhisa
Mitsujiro Osawa
Atsushi Iwama
Kaho Harada
Kiyoka Saito
Tetsuya Taga/DEVELOPMENT GROWTH & DIFFERENTIATION
- Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters/Ikuo Nobuhisa
Mitsujiro Osawa
Mami Uemura
Yoko Kishikawa
Maha Anani
Kaho Harada
Haruna Takagi
Kiyoka Saito
Masami Kanai-Azuma
Yoshiakira Kanai
Atsushi Iwama
Tetsuya Tagaa/Molecular and Cellular Biology
- Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice/Mami Uemura
Aisa Ozawa
Takumi Nagata
Kaoruko Kurasawa
Naoki Tsunekawa
Ikuo Nobuhisa
Tetsuya Taga
Kenshiro Hara
Akihiko Kudo
Hayato Kawakami
Yukio Saijoh
Masamichi Kurohmaru
Masami Kanai-Azuma
Yoshiakira Kanai/Development (Cambridge)
- CD45(low)c-Kit(high) cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region/Ikuo Nobuhisa
Shoutarou Yamasaki
Ahmed Ramadan
Tetsuya Taga/EXPERIMENTAL CELL RESEARCH
- Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression/Shoutarou Yamasaki
Ikuo Nobuhisa
Ahmed Ramadan
Tetsuya Taga/DEVELOPMENT GROWTH & DIFFERENTIATION
- Cells with hematopoietic activity in the mouse placenta reside in side population/Ahmed Ramadan
Ikuo Nobuhisa
Shoutarou Yamasaki
Naomi Nakagata
Tetsuya Taga/GENES TO CELLS
- Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. Inoue T
Kagawa T
Inoue-Mochita M
Isono K
Ohtsu N
Nobuhisa I
Fukushima M
Tanihara H
Taga T FEBS Letters 2010-06
- Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. Inoue T
Kagawa T
Inoue-Mochita M
Isono K
Ohtsu N
Nobuhisa I
Fukushima M
Tanihara H
Taga T FEBS Letters 2010-06
- Identification of the B Subtype of gamma Phospholipase A(2 9 Inhibitor from Protobothrops flavoviridis Serum and Molecular Evolution of Snake Serum Phospholipase A(2) Inhibitors. So S
Chijiwa T
Ikeda N
Nobuhisa I
Oda-Ueda N
Hattori S
Ohno M J Mol Evol 2008-03
- Identification of the B Subtype of gamma Phospholipase A(2 9 Inhibitor from Protobothrops flavoviridis Serum and Molecular Evolution of Snake Serum Phospholipase A(2) Inhibitors. J Mol Evol 2008-03
- Identification of a population of cells with hematopoietic stem cell properties in mouse aorta-gonad-mesonephros cultures/Ikuo Nobuhisa
Naoki Ohtsu
Seiji Okada
Naomi Nakagata
Tetsuya Taga/EXPERIMENTAL CELL RESEARCH
- Inhibitory effects of homeodomain-interacting protein kinase 2 on the aorta-gonad-mesonephros hematopoiesis/Naoki Ohtsu
Ikuo Nobuhisa
Miyuki Mochita
Tetsuya Taga/EXPERIMENTAL CELL RESEARCH
- Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47(phox) in recognition of a polyproline type II helix and an adjacent alpha-helix of p22(phox)/Nobuhisa, I
R Takeya
K Ogura
N Ueno
D Kohda
F Inagaki
H Sumimoto/BIOCHEMICAL JOURNAL
- Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk/H Takizawa
C Kubo-Akashi
Nobuhisa, I
SM Kwon
M Iseki
T Taga
K Takatsu
S Takaki/BLOOD
- Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk/H Takizawa
C Kubo-Akashi
Nobuhisa, I
SM Kwon
M Iseki
T Taga
K Takatsu
S Takaki/BLOOD
- NMR solution structure of the tandem SH3 domains of p47phox complexed with a p22phox –derived proline-rich peptide. Ogura K
Nobuhisa I
Yuzawa S
Takeya R
Torikai S
Saikawa K
Sumimoto H
Inagaki F J Bioi Chem 2006-02
- NMR solution structure of the tandem SH3 domains of p47phox complexed with a p22phox –derived proline-rich peptide. Ogura K
Nobuhisa I
Yuzawa S
Takeya R
Torikai S
Saikawa K
Sumimoto H
Inagaki F J Bioi Chem 2006-02
- A region C-terminal to the proline-rich core of p47(phox) regulates activation of the phagocyte NADPH oxidase by interacting with the C-terminal SH3 domain of p67(phox)/K Mizuki
R Takeya
F Kuribayashi
Nobuhisa, I
D Kohda
H Nunoi
K Takeshige
H Sumimoto/ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- A region C-terminal to the proline-rich core of p47(phox) regulates activation of the phagocyte NADPH oxidase by interacting with the C-terminal SH3 domain of p67(phox)/K Mizuki
R Takeya
F Kuribayashi
Nobuhisa, I
D Kohda
H Nunoi
K Takeshige
H Sumimoto/ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture/M Yanagisawa
K Nakashima
W Ochiai
T Takizawa
T Setoguchi
A Uemura
M Takizawa
Nobuhisa, I
T Taga/NEUROSCIENCE RESEARCH
- Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture/M Yanagisawa
K Nakashima
W Ochiai
T Takizawa
T Setoguchi
A Uemura
M Takizawa
Nobuhisa, I
T Taga/NEUROSCIENCE RESEARCH
- Targeted disruption of the mouse ELYS gene results in embryonic lethality at peri-implantation development. Genes Cells 2004-11
- Targeted disruption of the mouse ELYS gene results in embryonic lethality at peri-implantation development. Okita K
Kiyonari H
Nobuhisa I
Kimura N
Aizawa S
Taga T Genes Cells 2004-11
- Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan. Chijiwa T
Deshimaru M
Nobuhisa I
Nakai M
Ogawa T
Oda N
Nakashima K
Fukumaki Y
Shimohigashi Y
Hattori S
Ohno M Biochem J 2004-04
- Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan. Chijiwa T
Deshimaru M
Nobuhisa I
Nakai M
Ogawa T
Oda N
Nakashima K
Fukumaki Y
Shimohigashi Y
Hattori S
Ohno M Biochem J 2004-04
- Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation/Nobuhisa, I
R Kato
H Inoue
M Takizawa
K Okita
A Yoshimura
T Taga/JOURNAL OF EXPERIMENTAL MEDICINE
- Negative regulation of hematopoiesis by the fused in myeloproliferative disorders gene product. Biochem Biophys Res Commun 2004-01
- Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein. Mol Cell Biol 2003-12
- Genomic organization and characterization of the mouse ELYS gene. Biochem Biophys Res Commun 2003-05
- Requirement of gp130 signaling for the AGM hematopoiesis. Exp Hematol 2003-04
- Interisland evolution of Trimeresurus flavoviridis venom phospholipase A(2) isozymes/T Chijiwa
Y Yamaguchi
T Ogawa
M Deshimaru
Nobuhisa, I
K Nakashima
N Oda-Ueda
Y Fukumaki
S Hattori
M Ohno/JOURNAL OF MOLECULAR EVOLUTION
- Interisland Evolution of Trimeresurus flavoviridis Venom Phospholipase A2 Isozymes. J Mol Evol 2003-03
- Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. Genes Cells 2002-04
- Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Biochem Biophys Res Commun 2001-09
- Regional and accelerated molecular evolution in group I snake venom gland phospholipase A(2) isozymes/Y Chuman
Nobuhisa, I
T Ogawa
M Deshimaru
T Chijiwa
NH Tan
Y Fukumaki
Y Shimohigashi
F Ducancel
JC Boulain
A Menez
M Ohno/TOXICON
- Regional and accelerated molecular evolution in group I snake venom gland phospholipase A(2) isozymes/Y Chuman
Nobuhisa, I
T Ogawa
M Deshimaru
T Chijiwa
NH Tan
Y Fukumaki
Y Shimohigashi
F Ducancel
JC Boulain
A Menez
M Ohno/TOXICON
- Structural elements of Trimeresurus flavoviridis serum inhibitors for recognition of its venom phospholipase A(2) isozymes/Nobuhisa, I
T Chiwata
Y Fukumaki
S Hattori
Y Shimohigashi
M Ohno/FEBS LETTERS
- Retrotransposable CR1-like elements in crotalinae snake genomes/Nobuhisa, I
T Ogawa
M Deshimaru
T Chijiwa
K Nakashima
Y Chuman
Y Shimohigashi
Y Fukumaki
S Hattori
M Ohno/TOXICON
- Structural elements of Trimeresurus flavoviridis serum inhibitors for recognition of its venom phospholipase A(2) isozymes/Nobuhisa, I
T Chiwata
Y Fukumaki
S Hattori
Y Shimohigashi
M Ohno/FEBS LETTERS
- Retrotransposable CR1-like elements in crotalinae snake genomes/Nobuhisa, I
T Ogawa
M Deshimaru
T Chijiwa
K Nakashima
Y Chuman
Y Shimohigashi
Y Fukumaki
S Hattori
M Ohno/TOXICON
- Characterization and evolution of a gene encoding a Trimeresurus flavoviridis serum protein that inhibits basic phospholipase A(2) isozymes in the snake's venom/Nobuhisa, I
S Inamasu
M Nakai
A Tatsui
T Mimori
T Ogawa
Y Shimohigashi
Y Fukumaki
S Hattori
H Kihara
M Ohno/EUROPEAN JOURNAL OF BIOCHEMISTRY
- Characterization and evolution of a gene encoding a Trimeresurus flavoviridis serum protein that inhibits basic phospholipase A(2) isozymes in the snake's venom/Nobuhisa, I
S Inamasu
M Nakai
A Tatsui
T Mimori
T Ogawa
Y Shimohigashi
Y Fukumaki
S Hattori
H Kihara
M Ohno/EUROPEAN JOURNAL OF BIOCHEMISTRY
- Structures of genes encoding phospholipase A(2) inhibitors from the serum of Trimeresurus flavoviridis snake/Nobuhisa, I
M Deshimaru
T Chijiwa
K Nakashima
T Ogawa
Y Shimohigashi
Y Fukumaki
S Hattori
H Kihara
M Ohno/GENE
- Structures of genes encoding phospholipase A(2) inhibitors from the serum of Trimeresurus flavoviridis snake/Nobuhisa, I
M Deshimaru
T Chijiwa
K Nakashima
T Ogawa
Y Shimohigashi
Y Fukumaki
S Hattori
H Kihara
M Ohno/GENE
- Accelerated evolution of snake venom phospholipase A(2) isozymes for acquisition of diverse physiological functions/T Ogawa
K Nakashima
Nobuhisa, I
M Deshimaru
Y Shimohigashi
Y Fukumaki
Y Sakaki
S Hattori
M Ohno/TOXICON
- Accelerated Evolution of Crotalinae Snake Venom Gland Serine Proteases. Deshimaru M
Ogawa T
Nakashima K
Nobuhisa I
Chijiwa T
Shimohigashi Y
Fukumaki Y
Niwa M
Yamashina I
Hattori S
Ohno M FEBS Letters 1996-11
- Accelerated evolution of snake venom phospholipase A(2) isozymes for acquisition of diverse physiological functions/T Ogawa
K Nakashima
Nobuhisa, I
M Deshimaru
Y Shimohigashi
Y Fukumaki
Y Sakaki
S Hattori
M Ohno/TOXICON
- Accelerated Evolution of Crotalinae Snake Venom Gland Serine Proteases. FEBS Letters 1996-11
- Accelerated evolution of Trimeresurus okinavensis venom gland phospholipase A(2) isozyme-encoding genes/Nobuhisa, I
K Nakashima
M Deshimaru
T Ogawa
Y Shimohigashi
Y Fukumaki
Y Sakaki
S Hattori
H Kihara
M Ohno/GENE
- Accelerated evolution of Trimeresurus okinavensis venom gland phospholipase A(2) isozyme-encoding genes/Nobuhisa, I
K Nakashima
M Deshimaru
T Ogawa
Y Shimohigashi
Y Fukumaki
Y Sakaki
S Hattori
H Kihara
M Ohno/GENE
- ACCELERATED EVOLUTION IN THE PROTEIN-CODING REGIONS IS UNIVERSAL IN CROTALINAE SNAKE-VENOM GLAND PHOSPHOLIPASE A(2) ISOZYME GENES/KI NAKASHIMA
NOBUHISA, I
M DESHIMARU
M NAKAI
T OGAWA
Y SHIMOHIGASHI
Y FUKUMAKI
M HATTORI
Y SAKAKI
S HATTORI
M OHNO/PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ACCELERATED EVOLUTION IN THE PROTEIN-CODING REGIONS IS UNIVERSAL IN CROTALINAE SNAKE-VENOM GLAND PHOSPHOLIPASE A(2) ISOZYME GENES/KI NAKASHIMA
NOBUHISA, I
M DESHIMARU
M NAKAI
T OGAWA
Y SHIMOHIGASHI
Y FUKUMAKI
M HATTORI
Y SAKAKI
S HATTORI
M OHNO/PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- STRUCTURES OF GENES ENCODING TATA BOX-BINDING PROTEINS FROM TRIMERESURUS-GRAMINEUS AND T-FLAVOVIRIDIS SNAKES/K NAKASHIMA
NOBUHISA, I
M DESHIMARU
T OGAWA
Y SHIMOHIGASHI
Y FUKUMAKI
M HATTORI
Y SAKAKI
S HATTORI
M OHNO/GENE
- STRUCTURES OF GENES ENCODING TATA BOX-BINDING PROTEINS FROM TRIMERESURUS-GRAMINEUS AND T-FLAVOVIRIDIS SNAKES/K NAKASHIMA
NOBUHISA, I
M DESHIMARU
T OGAWA
Y SHIMOHIGASHI
Y FUKUMAKI
M HATTORI
Y SAKAKI
S HATTORI
M OHNO/GENE
- POLYMORPHISMS OF TRIMERESURUS-FLAVOVIRIDIS VENOM GLAND PHOSPHOLIPASE A(2) ISOZYME GENES/KI NAKASHIMA
NOBUHISA, I
T OGAWA
M HATTORI
Y SAKAKI
H KIHARA
M OHNO/BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- POLYMORPHISMS OF TRIMERESURUS-FLAVOVIRIDIS VENOM GLAND PHOSPHOLIPASE A(2) ISOZYME GENES/KI NAKASHIMA
NOBUHISA, I
T OGAWA
M HATTORI
Y SAKAKI
H KIHARA
M OHNO/BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Rasip1 is a novel Sox17 downstream target gene and cooperating factor for the maintenance of the hematopoietic cluster cells Melig G, Nobuhisa I, Kiyoka S, Tsukahara R, Itabashi A, Kanai Y, Kanai M, Taga T. 第46回分子生物学会年会 2023/12/08
- 胎生期に造血幹細胞が出現し維持される仕組み 信久幾夫、田賀哲也 第96回 日本生化学会大会 2023/11/02 日本生化学会
- Rasip1 helps maintenance of hematopoietic activities of mouse embryonic intra-aortic hematopoietic clusters. Melig G, Nobuhisa I, Kiyoka S, Tsukahara R, Itabashi A, Kanai Y, Kanai M, Taga T. 第44回日本炎症・再生医学会 2023/07/12
- Rasip1 gene functioning downstream of Sox17 maintains the hematopoietic cluster-forming cells in E10.5 mouse embryos. Melig G, Nobuhisa I, Kiyoka S, Tsukahara R, Itabashi A, Kanai Y, Kanai M, Taga T. 第20回幹細胞シンポジウム 2023/05/19
- Rasip1 is involved in the positive regulation of hematopoietic activity in E10.5 intra-aortic hematopoietic cluster cells Melig G
Nobuhisa I
Kiyoka S
Tsukahara R
Itabashi A
Kanai Y
Kanai M
Taga T 第45回分子生物学会年会 2022-12-01
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