論文

基本情報

氏名 熊谷 奈々
氏名(カナ) クマガイ ナナ
氏名(英語) KUMAGAI NANA
所属 中村学園大学 栄養科学部 栄養科学科
職名 講師

題名

Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats.

単著・共著の別

 

著者

Ian Fukudome
Michiya Kobayashi
Ken Dabanaka
Hiromichi Maeda
Ken Okamoto
Takehiro Okabayashi
Ryoko Baba
Nana Kumagai
Koji Oba
Mamoru Fujita
Kazuhiro Hanazaki

担当区分

 

概要

The level of plasma diamine oxidase (DAO) activity is associated with the maturation and integrity of small intestinal mucosa. This study in rats investigated whether a decreased level of plasma DAO could reflect the severity of mucosal injury due to intravenous 5-fluorouracil (5-FU) treatment. The beneficial effect of soluble dietary fiber (SDF) on preventing diarrhea after 5-FU treatment was also examined. To induce diarrhea, 5-FU (50 mg/kg/day for four days) was administered via the tail vein with or without SDF supplementation. After 5-FU treatment, the majority of rats developed moderate to severe diarrhea, and levels of plasma DAO activity significantly decreased compared to those of control group (P < 0.05). Scanning electron microscopy revealed disarrangement of the small intestinal villi. Contrarily, the rats supplemented with SDF had diarrhea less frequently (50.0 vs. 91.7 %, P = 0.025) on day five, and DAO activity levels were significantly higher than in those rats administered 5-FU alone (8.25 ± 5.34 vs. 5.50 ± 4.32, P = 0.023). In conclusion, plasma DAO activity decreases in response to severe intestinal mucosal injury after 5-FU treatment, and SDF supplementation might be a practical and useful treatment for reducing the intestinal toxicity of 5-FU.

発表雑誌等の名称

Medical molecular morphology

出版者

2

47

2

開始ページ

100

終了ページ

7

発行又は発表の年月

2014-06

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

国内誌

国際共著

 

ISSN

 

eISSN

 

DOI

10.1007/s00795-013-0055-7

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID