論文

基本情報

氏名 内田 和宏
氏名(カナ) ウチダ カズヒロ
氏名(英語) KAZUHIRO UCHIDA
所属 中村学園大学 栄養科学部 栄養科学科
職名 准教授

題名

Serum elaidic acid concentration and risk of dementia: The Hisayama study.

単著・共著の別

 

著者

Honda T
Ohara T
Shinohara M
Hata J
Toh R
Yoshida D
Shibata M
Ishida T
Hirakawa Y
Irino Y
Sakata S
Uchida K
Kitazono T
Kanba S
Hirata KI
Ninomiya T

担当区分

 

概要

OBJECTIVE: The associations between trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. METHODS: In total, 1,628 Japanese community residents aged 60 and older without dementia were followed prospectively from when they underwent a screening examination in 2002-2003 to November 2012 (median 10.3 years, interquartile range 7.2-10.4 years). Serum elaidic acid levels were measured using gas chromatography/mass spectrometry and divided into quartiles. The Cox proportional hazards model was used to estimate the hazard ratios for all-cause dementia, Alzheimer disease (AD), and vascular dementia by serum elaidic acid levels. RESULTS: During the follow-up, 377 participants developed some type of dementia (247 AD, 102 vascular dementia). Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for trend = 0.003) and AD (p for trend = 0.02) after adjustment for traditional risk factors. These associations remained significant after adjustment for dietary factors, including total energy intake and intakes of saturated and polyunsaturated fatty acids (both p for trend <0.05). No significant associations were found between serum elaidic acid levels and vascular dementia. CONCLUSIONS: The findings suggest that higher serum elaidic acid is a possible risk factor for the development of all-cause dementia and AD in later life. Public health policy to reduce industrially produced trans fatty acids may assist in the primary prevention of dementia.

発表雑誌等の名称

Neurology

出版者

 

93

22

開始ページ

e2053-e2064

終了ページ

 

発行又は発表の年月

2019-10

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

国際誌

国際共著

 

ISSN

 

eISSN

 

DOI

10.1212/WNL.0000000000008464

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID