論文

基本情報

氏名 大和 孝子
氏名(カナ) ヤマト タカコ
氏名(英語) TAKAKO YAMATO
所属 中村学園大学 栄養科学部 栄養科学科
職名 教授

題名

High saturated fatty acid intake induces insulin secretion by elevating gastric inhibitory polypeptide levels in healthy individuals

単著・共著の別

 

著者

Kazue Itoh
Ririko Moriguchi
Yuichiro Yamada
Misuzu Fujita
Takako Yamato
Masayo Oumi
Jens Juul Holst
Yutaka Seino

担当区分

 

概要

Insulin resistance is central to the etiology of the metabolic syndrome cluster of diseases. Evidence suggests that a high-fat diet is associated with insulin resistance, which may be modulated by dietary fatty acid composition. We hypothesized that high saturated fatty acid intake increases insulin and gastric inhibitory polypeptide (GIP) secretion. To clarify the effect of ingested fatty acid composition on glucose levels, we conducted an intervention study to investigate the insulin and plasma GIP responses in 11 healthy women, including a dietary control. Subjects were provided daily control meals (F-20; saturated fatty acids/monounsaturated fatty acids/polyunsaturated fatty acids [S/M/P] ratio, 3:4:3) with 20 energy (E) % fat, followed by 2 isoenergetic experimental meals for 7 days each. These meals comprised 605% carbohydrate, 15 E% protein, and 30 E% fat (FB-30; high saturated fatty acid meal; S/WP, 5:4:1; F-30: reduced saturated fatty acid meal; S/WP, 3:4:3). On the second day of the F-20 and the last day of F-30 and FB-30, blood samples were taken before and 30, 60, and 120 minutes after a meal tolerance test. The plasma glucose responses did not differbetween F-20 and FB-30 or F-30. However, insulin levels were higher after the FB-30 than after the F-20 (P < .01). The GIP response after the FB-30 was higher than that after the F-30 (P < .05). In addition, the difference in the incremental GIP between FB-30 and F-30 correlated significantly and positively with that of the insulin. These results suggest that a high saturated fatty acid content stimulates postprandial insulin release via increased GIP secretion. (C) 2014 Elsevier Inc. All rights reserved.

発表雑誌等の名称

NUTRITION RESEARCH

出版者

PERGAMON-ELSEVIER SCIENCE LTD

34

8

開始ページ

653

終了ページ

660

発行又は発表の年月

2014-08

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.1016/j.nutres.2014.07.013

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID