論文

基本情報

氏名 森口 里利子
氏名(カナ) モリグチ リリコ
氏名(英語) MORIGUCHI RIRIKO
所属 中村学園大学 栄養科学部 栄養科学科
職名 准教授

題名

Relationship between changes in serum leptin levels and blood pressure after weight loss

単著・共著の別

 

著者

K Itoh
K Imai
T Masuda
S Abe
M Tanaka
R Koga
H Itoh
T Matsuyama
M Nakamura

担当区分

 

概要

Insulin resistance is thought to raise blood pressure. Recently, a significant positive relationship between mean blood pressure and plasma leptin levels,but there have been no reports dealing with the relationship between blood pressure and either insulin resistance or serum leptin levels after weight loss. In the present work, we attempted to clarify the relationship between changes in blood pressure and either the serum leptin level or the insulin level in 102 moderately obese females (mean body mass index (BMI), 29.5+/-0.5 kg/m(2); age, 47.0+/-0.9) during a 3 month period. No differences in age, fat-mass, homeostasis model assessment (HOMA), the summation of insulin (SigmaIRI), plasma renin activity (PRA) or 24 h norepinephrine excretion (24hU-NE) were observed between the hypertensive (HT) group (n=31) and normotensive (NT) group (n=71) before weight loss, but the basal serum leptin was significantly higher in the HT (16.8+/-1.1 ng/ml) than in the NT group (15.2+/-0.8 ng/ml), after adjusting for abdominal total fat. After a 3 month weight reduction program, the total abdominal fat, serum leptin and SigmaIRI significantly decreased in both groups. The systolic blood pressure (SBP)/diastolic blood pressure (DBP) significantly decreased from 144/84 to 130/77 mmHg only in the HT but not in the NT group. The PRA decreased in both groups, while the 24hU-NE significantly decreased only in the HT group. The changes in the leptin level were significantly correlated with the changes in both SigmaIRI and HOMA after weight loss in the two groups, respectively. Finally, a statistically significant positive correlation was observed between the changes in the leptin and the changes in the mean blood pressure (MBP) (r=0.412, p<0.05) only in the HT group. Multiple regression analysis revealed that the changes in MBP were independently associated with the changes in 24hU-NE and the changes in either SigmaIRI or HOMA in all subjects. However, a statistically significant positive correlation was observed between the changes in MBP and the changes in leptin levels even after adjusting for the total abdominal fat, 24hU-NE and either SigmaIRI or HOMA (both expressed as a percentage of the baseline value) in a multiple regression analysis only in the HT group. These results suggest that leptin may play a role in the pathophysiology of obese hypertension.

発表雑誌等の名称

HYPERTENSION RESEARCH

出版者

JAPANESE SOC HYPERTENSION CENT ACADEMIC SOC, PUBL OFFICE

25

6

開始ページ

881

終了ページ

886

発行又は発表の年月

2002-11

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.1291/hypres.25.881

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID