論文

基本情報

氏名 森口 里利子
氏名(カナ) モリグチ リリコ
氏名(英語) MORIGUCHI RIRIKO
所属 中村学園大学 栄養科学部 栄養科学科
職名 准教授

題名

Subcutaneous fat accumulation shows a beneficial correlation with serum cholesterol in postmenopausal Japanese women

単著・共著の別

 

著者

Misuzu Tanaka
Ririko Koga
Hiroko Tsuda
Katsumi Imai
Shimako Abe
Takashi Masuda
Masako Iwamoto
Eri Nakazono
Tomoko Kamohara
Naoko Kinukawa
Toshhe Sakata

担当区分

 

概要

This study aimed to investigate whether accumulation of subcutaneous abdominal fat has a beneficial correlation with lipid metabolism in premenopausal and/or postmenopausal Japanese women. The study enrolled 146 premenopausal women, ranging in age from 19 to 54 years, and 82 postmenopausal women, ranging in age from 47 to 66 years. Fat distribution, including abdominal visceral fat area (VFA) and abdominal subcutaneous fat area (SFA), were measured in an outpatient clinic by magnetic resonance imaging. Homogeneity of the regression slopes for SFA to total cholesterol (P = 0.030), low-density lipoprotein cholesterol (P= 0.020), apolipoprotein B (apoB) (P = 0.001), and the ratio of apoB to apolipoprotein A-1 (apoA-1) (P = 0.003) were not found between premenopausal and postmenopausal women, even after adjustment for both VFA and age. However, the regression slopes for VFA to all measured lipid parameters, as well as apolipoproteins, were homogeneous between the premenopausal and postmenopausal groups. Abdominal SFA in postmenopausal women correlated negatively with total cholesterol (P = 0.007), low-density lipoprotein cholesterol (P = 0.002), apoB (P < 0.001), and the ratio of apoB to apoA-1 (P = 0.001), after adjustment for age and VFA, but this was not the case in premenopausal women. The mechanisms involved in the beneficial effects of subcutaneous fat accumulation in postmenopausal women remain obscure, but upregulated aromatase expression, derived from adipose tissue, may possibly improve lipid and apolipoprotein metabolism.

発表雑誌等の名称

EXPERIMENTAL BIOLOGY AND MEDICINE

出版者

SOC EXPERIMENTAL BIOLOGY MEDICINE

232

8

開始ページ

1064

終了ページ

1070

発行又は発表の年月

2007-09

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.3181/0610-RM-257

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID