論文

基本情報

氏名 竹嶋 美夏子
氏名(カナ) タケシマ ミカコ
氏名(英語) MIKAKO TAKESHIMA
所属 中村学園大学 栄養科学部 フード・マネジメント学科
職名 准教授

題名

Antiproliferative and Apoptosis-inducing Activity of Nobiletin Against Three Subtypes of Human Breast Cancer Cell Lines

単著・共著の別

 

著者

Chen Chen
Misaki Ono
Mikako Takeshima
Shuji Nakano

担当区分

 

概要

Although nobiletin has a potent antitumor activity against several types of human cancers, its inhibitory effects and possible mechanisms of action on breast cancer cells with different hormone receptor and HER2 status remains unknown. Materials and Methods: Using hormone receptor-positive MCF-7, HER2-positive SK-BR-3, and triple-negative MDA-MB-468 cell lines, we investigated the antitumor mechanisms of nobiletin. Results: Nobiletin exhibited dose- and time-dependent antitumor activity against these different subtypes of cell lines, with the greatest inhibition observed against the MDA-MB-468 cell line. Nobiletin induced cell-cycle arrest at the G(0)/G(1) phase by suppressing ERK1/2 activity, with concomitant cyclin-D1 suppression and p21 up-regulation. Nobiletin induced apoptotic cell death by reducing Bcl-xL expression, without affecting Bax levels, and inhibited the activity of AKT and downstream mTOR in MDA-MB-468 cells, but not in other cell lines. Conclusion: The predominant anticancer activity of nobiletin in MDA-MB-468 cells suggests a potential role of nobiletin for the prevention of triple-negative breast cancer.

発表雑誌等の名称

ANTICANCER RESEARCH

出版者

INT INST ANTICANCER RESEARCH

34

4

開始ページ

1785

終了ページ

1792

発行又は発表の年月

2014-04

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

 

国際共著

 

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Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

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