論文

基本情報

氏名 竹嶋 美夏子
氏名(カナ) タケシマ ミカコ
氏名(英語) MIKAKO TAKESHIMA
所属 中村学園大学 栄養科学部 フード・マネジメント学科
職名 准教授

題名

Differential Anticancer Activity of Pterostilbene Against Three Subtypes of Human Breast Cancer Cells

単著・共著の別

 

著者

Rei Wakimoto
Misaki Ono
Mikako Takeshima
Takako Higuchi
Shuji Nakano

担当区分

 

概要

Although pterostilbene, a natural analog of resveratrol, has potent antitumor activity against several human cancer types, the possible inhibitory mechanisms against subtypes of human breast cancer with different hormone receptor and human epidermal growth factor receptor 2 (HER2) status remain unknown. We investigated the anticancer activity of pterostilbene using three subtypes of breast cancer cell lines. Pterostilbene treatment exhibited a dose-dependent antiproliferative activity, with the greatest growth inhibition observed in triple-negative MDA-MB-468 cells. Although pterostilbene arrested cell-cycle progression at the G(0)/G(1) phase regardless of breast cancer subtype, its apoptosis-inducing activity was highly apparent in MDA-MB-468 cells. Pterostilbene induced strong and sustained activation of extracellular signal-regulated kinase (ERK) 1/2, with concomitant cyclin D1 suppression and p21 up-regulation, and inhibited the phosphorylation of AKT and mammalian target of rapamycin (mTOR), followed by subsequent up-regulation of BAX without affecting B-cell lymphoma-extra large (BCL-xL). Oral administration of pterostilbene significantly suppressed tumor growth in nude mice xenotransplanted with MDA-MB-468 cells. These data suggest a potential role of pterostilbene for prevention and treatment of human breast cancer, especially of triple-negative breast cancer.

発表雑誌等の名称

ANTICANCER RESEARCH

出版者

INT INST ANTICANCER RESEARCH

37

11

開始ページ

6153

終了ページ

6159

発行又は発表の年月

2017-11

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.21873/anticanres.12064

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID