論文

基本情報

氏名 島田 淳巳
氏名(カナ) シマダ アツミ
氏名(英語) SHIMADA ATSUMI
所属 短期大学部 食物栄養学科
職名 教授

題名

Pentacyclic triterpene acids, rotungenic acid and barbinervic acid, from fresh leaves of Diospyros kaki Thunberg and their glutaminase inhibitory activities.

単著・共著の別

 

著者

Shimada A
Ueno H
Yamamoto K
Kawabata K
Inagaki M

担当区分

 

概要

Glutaminase is an important target that is often over-expressed in neurodegenerative and lifestyle-related diseases but few effective inhibitors of this enzyme have yet reached clinical trials. Three compounds isolated from fresh leaves of Diospyros kaki Thunberg, ursolic acid (1), rotungenic acid (2) and barbinervic acid (3), were identified by analyzing their NMR and MS spectral data and comparison of these with reported data. The IC50 values of 1-3 and 6-diazo-5-oxo-L-norleucine (DON) as control were 775, 13, 14, and 434 μM, respectively. Compounds 2 and 3 showed higher glutaminase inhibitory activities than DON. Compounds 2 and 3 may serve as potential lead compounds for the prevention and treatment of neurodegenerative and lifestyle-related diseases by targeting glutaminase. This is the first report on glutaminase inhibitory activities of 2 and 3.

発表雑誌等の名称

Natural Product Research.

出版者

 

 

 

開始ページ

14786419

終了ページ

5

発行又は発表の年月

2022-12

査読の有無

無し

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

国際誌

国際共著

 

ISSN

 

eISSN

 

DOI

10.1080/14786419.2022.2150765

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID