[Metabolism of 2,2',4,5,5'-pentachlorobiphenyl (CB101) by liver microsomes of rats, hamsters and guinea pigs].

Ohta C
Matsuoka M
Haraguchi K
Kato Y
Endo T
Koga N

特集号 油症とPCB及びダイオキシン関連化合物 研究報告 第21集Our previous studies have shown that six metabolites, namely 3-hydroxy (OH)-, 3'- OH-, 4'-OH-, 3',4'-dihydroxy (diOH)-, 3'-methylsulfone (CH3SO2)- and 4'-CH3SO2-2,2',4,5,5'- pentachlorobiphenyl (CB101),were found in the serum and liver of rats,hamsters and guinea pigs 4 days after administration of CB101. In this study, the in vitro metabolism of CB101 was studied using liver microsomes of rats, hamsters and guinea pigs, and the effect of cytochrome P450 inducers, phenobarbital (PB) and 3-methylcholanthrene (MC) on CB101 metabolism was also compared. 3-OH-, ...

Fukuoka igaku zasshi = Hukuoka acta medica

福岡医学会

10.15017/6146

https://doi.org/10.15017/6146
http://ci.nii.ac.jp/naid/120000987159
http://ci.nii.ac.jp/ncid/AN00215478
https://www.ncbi.nlm.nih.gov/pubmed/17642303