特集号 油症とPCB及びダイオキシン関連化合物 研究報告第22集 責任編集者 古江増隆The Twenty-second Reports of the Study on Yusho―PCBs and Dioxin-Related Compounds―Guest Editor Masutaka FurueOur preceding studies have reported that 2,2',5,5'-tetrachlorobiphenyl (tetraCB)(CB52) is mainly metabolized to 3-hydroxy (OH)-metabolite by phenobarbital (PB)-inducible cytochrome P450 (P450) isoforms such as CYP2B1 and CYP2B18. In this study, the metabolism of CB52 by liver microsomes of untreated and PB-treated rabbits was investigated. Rabbit liver microsomes produced mainly 3-OH- and 4-OH-metabolites (M-1 and M-2) at an equal extent and...
