論文

基本情報

氏名 太田 千穂
氏名(カナ) オオタ チホ
氏名(英語) CHIHO OHTA
所属 中村学園大学 栄養科学部 栄養科学科
職名 准教授

題名

Possible mechanism for the polychlorinated biphenyl-induced liver-selective accumulation of thyroxine in rats

単著・共著の別

 

著者

Yoshihisa Kato
Aki Fujii
Koichi Haraguchi
Yukiko Fujii
Kazutaka Atobe
Tetsuya Endo
Osamu Kimura
Nobuyuki Koga
Chiho Ohta
Shizuo Yamada
Masakuni Degawa

担当区分

 

概要

We have previously reported that decrease in level of serum thyroxine T-4 by Kanechor 500 (KC500) in rats would occur through the increase in hepatic T-4 accumulation rather than the increase in hepatic T-4-glucuronyl transferase activity. In the present study, to understand the mechanism underlying the KC500-mediated increase in hepatic T-4 accumulation, we examined the relationship between the KC500-mediated changes in hepatic T-4 accumulation and the expression levels of mRNAs of hepatic transporters including T-4 transporters. [I-5(12)]T-4 was intravenously injected into KC500-pretreated and control (KC500-untreated) Wistar rats, and [I-5(12)]T-4 uptake levels of liver parenchymal cells were comparatively examined. The amount of [I-5(12)]T-4 uptake by hepatic cells increased in a time-dependent manner up to 96 hr after KC500 treatment. Following KC500 treatment, a time-dependent increase in the mRNA level of hepatic T-4 influx transporter LAT1 was observed up to 96 hr later, while a significant increase in hepatic T-4 influx transporter Oatp2 mRNA occurred only at 96 hr later. No KC500-mediated increases in the mRNAs of other hepatic transporters(Oatp1, Oatp3,Oatp4, Ntcp, LAT2, and Mrp2) were observed at any timepoints, although the mRNA expression of the T-4 conjugate(s) efflux transporter Mrp3 significantly increased in a time-dependent manner 24-96 hr following KC500 treatment. The present findings suggest that KC500-mediated increase in hepatic T-4 accumulation occurs, at least in part, through the increase in the expression of hepatic T-4-transporters, such as LAT1 and Oatp2.

発表雑誌等の名称

JOURNAL OF TOXICOLOGICAL SCIENCES

出版者

JAPANESE SOC TOXICOLOGICAL SCIENCES

42

6

開始ページ

663

終了ページ

669

発行又は発表の年月

2017-12

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.2131/jts.42.663

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID