MISC

基本情報

氏名 太田 千穂
氏名(カナ) オオタ チホ
氏名(英語) CHIHO OHTA
所属 中村学園大学 栄養科学部 栄養科学科
職名 准教授

題名

A possible mechanism for 2,2 ',4,4 ',5,5 '-hexachlorobiphenyl-mediated decrease in serum thyroxine level in mice

単著・共著の別

 

著者

Yoshihisa Kato
Mao Onishi
Koichi Haraguchi
Shinichi Ikushiro
Chiho Ohta
Nobuyuki Koga
Tetsuya Endo
Shizuo Yamada
Masakuni Degawa

担当区分

 

概要

Serum total thyroxine (T-4) level was markedly decreased, without significant increases in the levels of hepatic T-4-UDP-glucuronosyltransferase (T-4-UGT) and serum thyroid-stimulating hormone, 3 days after treatment with 2,2',4,4',5,5'-hexachlorobiphenyl (CB153) (100 mg/kg, ip) in both 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive C57BL/6 and TCDD-resistant DBA/2 mice. Likewise, in either strain of mice, no CB153-mediated changes in the binding levels of [I-125]T-4 to serum proteins, such as transthyretin, albumin, and thyroxine binding globulin, were observed, while in CB153-pretreated C57BL/6 mice, but not in CB153-pretreated DBA/2 mice, the levels of biliary [I-125]T-4 and [I-125]T-4-glucuronide at 90-120 min after injection of [I-125]T-4 slightly increased, as compared with those in the corresponding control mice. Concerning tissue distribution of [I-125]T-4, liver-selective increases in the [I-125[T-4 accumulation by CB153-pretreatment were observed in both C57BL/6 and DBA/2 mice, and the hepatic levels of [I-125]T-4 in the C57BL/6 and DBA/2 mice became more than 44% and 34% of the [I-125]T-4 dosed, respectively. The present findings indicated that the C8153-mediated decreases in the level of serum total T-4 in C57BL/6 and DBA/2 mice occur mainly through an increase in the accumulation of T-4 in the liver. (C) 2011 Elsevier Inc. All rights reserved.

発表雑誌等の名称

TOXICOLOGY AND APPLIED PHARMACOLOGY

出版者

ACADEMIC PRESS INC ELSEVIER SCIENCE

254

1

開始ページ

48

終了ページ

55

発行又は発表の年月

2011-07

査読の有無

無し

依頼の有無

無し

記述言語

英語

掲載種別

 

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.1016/j.taap.2011.04.020

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID