Effects of atypical antipsychotic drugs vs. haloperidol on expression of beat shock protein in the discrete brain regions of phencyclidine-treated rats

T Nakahara
T Kuroki
H Hondo
T Tsutsumi
K Fukuda
H Yao
H Uchimura

Haloperidol augmented a trend of an increase in the heat shock protein (hsp70) mRNA levels induced by phencyclidine (PCP) in rat medial prefrontal cortex, nucleus accumbens and striatum, while the atypical antipsychotic drugs such as clozapine, olanzapine and risperidone decreased it. When administered alone, clozapine, but not haloperidol, decreased hsp70 mRNA levels. Haloperidol and the atypical antipsychotic drugs may thus have differential effects on hsp70 expression in some brain regions of PCP-treated rats. (C) 1999 Elsevier Science B.V. All rights reserved.

MOLECULAR BRAIN RESEARCH

ELSEVIER SCIENCE BV

10.1016/S0169-328X(99)00248-X

http://ci.nii.ac.jp/naid/10021188972
https://doi.org/10.1016/S0169-328X(99)00248-X
https://www.ncbi.nlm.nih.gov/pubmed/10581414
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000083911200023&DestApp=WOS_CPL