Hypothalamic neuronal histamine is a derivative of histidine. It has been shown to both suppress food intake and accelerate lipolysis as a target of leptin in rats. The present study aimed to examine whether or not histidine intake affects feeding suppression, lipolysis and the serum leptin concentration in moderately obese women. The subjects were 118 moderately obese females (mean BMI 29.2±0.3kg/m2, mean age 46.9±0.8 years) who participated in a weight reduction program for three months. Blood sampling and a nutritional survey were carried out, and the subjects' weight was measured before...
