論文

基本情報

氏名 今井 克己
氏名(カナ) イマイ カツミ
氏名(英語) KATSUMI IMAI
所属 中村学園大学 栄養科学部 栄養科学科
職名 教授

題名

Association between blood pressure and insulin resistance in obese females during weight loss and weight rebound phenomenon

単著・共著の別

 

著者

K Itoh
K Imai
T Masuda
S Abe
M Tanaka
R Koga
H Itoh
M Nakamura

担当区分

 

概要

The purpose of this study was to investigate the effect of weight loss on blood pressure and its related variables in moderately obese Japanese females, including an investigation of the rebound phenomenon. Study I examined the effects of weight loss on blood pressure in 138 moderately obese, nondiabetic females (BMI 29.3 +/- 0.3 kg/m(2); age, 46.3 +/- 0.8 years) during a 3-month therapeutic dietary and exercise program. Study II investigated the effect of weight rebound on blood pressure over an additional 21 months of exercise in 48 subjects from Study I subjects. After 3 months, the BMI significantly decreased to 27.9 +/- 0.3 kg/m(2). Abdominal total fat, visceral fat (V), and subcutaneous fat (S) also decreased significantly. In addition, the summation of insulin (Sigma IRI), plasma glucose (Sigma PG) and HOMA during 75 g oral glucose tolerance test also all significantly decreased. Significant decreases in both the SBP and DBP were observed after the 3 month weight reduction program. Multiple regression analysis revealed that the reduction in SBP was significantly and positively associated with the reduction in log ZIA] and the reduction in log 24h-urinary norepinephrine excretion at the end of Study I. The DBP showed a significantly positive association with the log Sigma IRI. With regard to the weight rebound phenomenon, Study II showed that the SBP, DBP and Sigma IRI all increased significantly, and a positive correlation was observed between the changes in the SBP and those in the log Sigma IRI. However, no such correlation was observed regarding the abdominal total fat and visceral fat during both periods. These results suggest that weight loss therefore caused the BP to decrease due to both an improvement in hyperinsulinemia and a decrease in the adrenergic activity which may be involved in the urinary catecholamine. As a result, hyperinsulinemia is thus considered to play an important role in the pathogenesis of blood pressure due to obesity not only during weight loss, but also during the weight rebound phenomenon.

発表雑誌等の名称

HYPERTENSION RESEARCH

出版者

JAPANESE SOC HYPERTENSION CENT ACADEMIC SOC, PUBL OFFICE

24

5

開始ページ

481

終了ページ

487

発行又は発表の年月

2001-09

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.1291/hypres.24.481

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID