論文

基本情報

氏名 河手 久弥
氏名(カナ) カワテ ヒサヤ
氏名(英語) HISAYA KAWATE
所属 中村学園大学 栄養科学部 栄養科学科
職名 教授

題名

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

単著・共著の別

共著

著者

Teruhisa Tsuzuki
Akinori Egashira
Hisato Igarashi
Tomoo Iwakuma
Yoko Nakatsuru
Yohei Tominaga
Hisaya Kawate
Kazuki Nakao
Kenji Nakamura
Fumio Ide
Shinobu Kura
Yusaku Nakabeppu
Motoya Katsuki
Takatoshi Ishikawa
Mutsuo Sekiguchi

担当区分

概要

Oxygen radicals, which can be produced through normal cellular metabolism, are thought to play an important role in mutagenesis and tumorigenesis. Among various classes of oxidative DNA damage, 8-oxo-7,8-dihydroguanine (8-oxoG) is most important because of its abundance and mutagenicity. The MTH1 gene encodes an enzyme that hydrolyzes 8-oxo-dGTP to monophosphate in the nucleotide pool, thereby preventing occurrence of transversion mutations. By means of gene targeting, we have established MTH1 gene-knockout cell lines and mice. When examined 18 months after birth, a greater number of tumors were formed in the lungs, livers, and stomachs of MTH1-deficient mice, as compared with wild-type mice. The MTH1-deficient mouse will provide a useful model for investigating the role of the MTH1 protein in normal conditions and under oxidative stress.

発表雑誌等の名称

Proceedings of the National Academy of Sciences of the United States of America

出版者

NATL ACAD SCIENCES

98

20

開始ページ

11456

終了ページ

11461

発行又は発表の年月

2001/09

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

国際共著

ISSN

eISSN

DOI

10.1073/pnas.191086798

Cinii Articles ID

Cinii Books ID

Pubmed ID

11572992

PubMed Central 記事ID

PMC58751

形式

無償ダウンロード

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID