論文

基本情報

氏名 河手 久弥
氏名(カナ) カワテ ヒサヤ
氏名(英語) HISAYA KAWATE
所属 中村学園大学 栄養科学部 栄養科学科
職名 教授

題名

Opposite effects of alternative TZF spliced variants on androgen receptor

単著・共著の別

共著

著者

Rong-Hua Tao
Hisaya Kawate
Keizo Ohnaka
Masamichi Ishizuka
Hiromi Hagiwara
Ryoichi Takayanagi

担当区分

概要

We previously demonstrated that testicular zinc-finger protein (TZF) was a corepressor of the androgen receptor (AR). In the present study, We further showed that TZF-L, an alternative spliced variant of TZF, enhanced transactivation function of AR. Deletion analysis of TZF-L revealed that its N-terminus, which almost corresponded to that of TZF, but not its C-terminus was able to interact with AR. Additional analysis suggested that TZF kind TZF-L were able to Form both homodimers and heterodimers. TZF-L inhibited the homodimer formation of TZF and the intracellular dot formation of TZF. We propose that in the unique regulation system of AR-mediated transactivation, two spliced isoforms of TZF act as coactivator and corepressor, respectively. (c) 2006 Elsevier Inc. All rights reserved.

発表雑誌等の名称

Biochemical and Biophysical Research Communications

出版者

ACADEMIC PRESS INC ELSEVIER SCIENCE

341

2

開始ページ

515

終了ページ

521

発行又は発表の年月

2006/03

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

国際共著

ISSN

0006-291X

eISSN

DOI

10.1016/j.bbrc.2005.12.213

Cinii Articles ID

Cinii Books ID

Pubmed ID

16446156

PubMed Central 記事ID

形式

無償ダウンロード

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID