論文

基本情報

氏名 河手 久弥
氏名(カナ) カワテ ヒサヤ
氏名(英語) HISAYA KAWATE
所属 中村学園大学 栄養科学部 栄養科学科
職名 教授

題名

Relation of coffee consumption and serum liver enzymes in Japanese men and women with reference to effect modification of alcohol use and body mass index

単著・共著の別

共著

著者

Mizuko Ikeda
Takako Maki
Guang Yin
Hisaya Kawate
Masahiro Adachi
Keizo Ohnaka
Ryoichi Takayanagi
Suminori Kono

担当区分

概要

Objective. Previous studies have shown that coffee consumption is inversely related to serum levels of liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), but few have addressed the relation in women and effect modifications of alcohol use and obesity. We examined the association of coffee and green tea consumption with serum activities of liver enzymes in free-living Japanese men and women, focusing on sex difference and effect modifications of alcohol and obesity. Material and methods. The data were derived from the baseline survey of the Kyushu University Fukuoka Cohort Study, and included 12,020 Japanese men and women aged 49-76 years who were free of chronic liver diseases. Results. There was an inverse association between coffee consumption and elevated ALT in men, and the association between the two was weaker in women. In the analyses stratified by aminotransferases category, inverse associations of coffee consumption with serum activities of liver enzymes were observed in both men and women within the whole range and among those with aminotransferases within the reference range (ALT/AST < 40 IU/L for men and ALT/AST < 30 IU/L for women). Inverse associations of coffee with liver enzymes were more evident in those with high alcohol consumption and in those with low body mass index. Conclusions. Coffee drinking probably confers protection against alcohol-related increase in liver enzymes.

発表雑誌等の名称

Scandinavian Journal of Clinical and Laboratory Investigation

出版者

INFORMA HEALTHCARE

70

3

開始ページ

171

終了ページ

179

発行又は発表の年月

2010/04

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

国際共著

ISSN

0036-5513

eISSN

DOI

10.3109/00365511003650165

Cinii Articles ID

Cinii Books ID

Pubmed ID

20205615

PubMed Central 記事ID

形式

無償ダウンロード

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID