論文

基本情報

氏名 河手 久弥
氏名(カナ) カワテ ヒサヤ
氏名(英語) HISAYA KAWATE
所属 中村学園大学 栄養科学部 栄養科学科
職名 教授

題名

Long-term study of subclinical Cushing's syndrome shows high prevalence of extra-adrenal malignancy in patients with functioning bilateral adrenal tumors

単著・共著の別

共著

著者

Hisaya Kawate
Michiko Kohno
Yayoi Matsuda
Yuko Akehi
Makito Tanabe
Keizo Ohnaka
Masatoshi Nomura
Toshihiko Yanase
Ryoichi Takayanagi

担当区分

概要

Subclinical Cushing's syndrome (SCS) is characterized by subtle autonomous cortisol secretion from adrenal tumors without specific signs and symptoms of hypercortisolism. Patients with SCS have a high prevalence of "lifestyle-related diseases," such as hypertension, diabetes mellitus, dyslipidemia, and osteoporosis. Long-term follow-up of SCS patients is reportedly indispensable for establishing indications for surgical treatment of SCS. We performed a follow-up survey of 27 patients with SCS (median: 5.3 years) and compared those who had undergone surgical treatment (n=15) with those who had not (n=12). The mean diameter of tumors was 31 mm; 16 (59%) patients had unilateral lesions and 11(41%) carried bilateral ones. In 67% and 60% of the treatment group, respectively, hypertension and diabetes mellitus improved. We also noticed that eight of 11(73%) SCS patients with bilateral adrenal tumors had extra-adrenal malignancies in various tissues. Interestingly, among nine SCS patients who had malignancies, eight showed bilateral adrenal uptake in I-131-aldosterol scintigraphy. The results imply that surgical treatment can reduce cardiovascular risks in SCS patients. Screening for malignancy may be necessary inpatients with bilateral adrenal tumors suspected of autonomous hypersecretion of cortisol from both sides.

発表雑誌等の名称

Endocrine Journal

出版者

JAPAN ENDOCRINE SOC

61

12

開始ページ

1205

終了ページ

1212

発行又は発表の年月

2014/12

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

国際共著

ISSN

1348-4540

eISSN

DOI

10.1507/endocrj.EJ14-0155

Cinii Articles ID

Cinii Books ID

Pubmed ID

25223468

PubMed Central 記事ID

形式

無償ダウンロード

無償ダウンロード不可

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID