論文

基本情報

氏名 小野 美咲
氏名(カナ) オノ ミサキ
氏名(英語) ONO MISAKI
所属 中村学園大学 栄養科学部 栄養科学科
職名 講師

題名

Mechanism of the Anticancer Effect of Lycopene (Tetraterpenoids)

単著・共著の別

 

著者

Misaki Ono
Mikako Takeshima
Shuji Nakano

担当区分

 

概要

Increasing evidence suggests that lycopene, a major carotenoid detected in human plasma, may be preventive against the formation and the development of different types of human cancers including prostate, breast, and lung cancer. Experimental studies demonstrated that lycopene inhibits the growth of various cancer cells of different organs and prevent chemically induced carcinogenesis in animal models. Although the excellent antioxidant property of lycopene is most likely the basis for its preventive role toward cancer, the direct anticancer activities of lycopene through multiple mechanisms are disclosed, including regulation of growth factor signaling, cell cycle arrest and/or apoptosis induction, and changes in antioxidant and phase II detoxifying enzymes. The anti-inflammatory activity of lycopene is also considered as an important determinant that suppresses the promotion and progression of carcinogenesis. Moreover, lycopene inhibits cell invasion, angiogenesis, and metastasis. Importantly, those activities have been shown to be exhibited at the physiologically attainable concentration in humans. Although the preclinical data strongly suggest an antitumor activity of lycopene, a number of epidemiological and intervention studies indicate that there is still no clear clinical evidence that supports its use for the prevention of those cancers. More well controlled clinical intervention trials are needed to further clarify the exact role of lycopene in the cancer prevention. Nonetheless, because of its multiple tumor-inhibitory activities, lycopene still remains to be an attractive and promising carotenoid that will potentially contribute to the prevention and treatment of human cancers. This chapter reviews data on the cancer preventive activities of lycopene, possible mechanisms involved, and the relationship between lycopene consumption and human cancer risk. © 2015 Elsevier Inc.

発表雑誌等の名称

Enzymes

出版者

Academic Press

37

 

開始ページ

139

終了ページ

166

発行又は発表の年月

2015

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

論文集(書籍)内論文

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.1016/bs.enz.2015.06.002

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

DOI

無償ダウンロード

無償ダウンロード不可

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID