論文

基本情報

氏名 日野 真一郎
氏名(カナ) ヒノ シンイチロウ
氏名(英語) HINO SHINICHIROU
所属 中村学園大学 栄養科学部 栄養科学科
職名 教授

題名

Activation of OASIS family, ER stress transducers, is dependent on its stabilization

単著・共著の別

 

著者

S. Kondo
S-I Hino
A. Saito
S. Kanemoto
N. Kawasaki
R. Asada
S. Izumi
H. Iwamoto
M. Oki
H. Miyagi
M. Kaneko
Y. Nomura
F. Urano
K. Imaizumi

担当区分

 

概要

Endoplasmic reticulum (ER) stress transducers transduce signals from the ER to the cytoplasm and nucleus when unfolded proteins accumulate in the ER. BBF2 human homolog on chromosome 7 (BBF2H7) and old astrocyte specifically induced substance (OASIS), ER-resident transmembrane proteins, have recently been identified as novel ER stress transducers that have roles in chondrogenesis and osteogenesis, respectively. However, the molecular mechanisms that regulate the activation of BBF2H7 and OASIS under ER stress conditions remain unresolved. Here, we showed that BBF2H7 and OASIS are notably unstable proteins that are easily degraded via the ubiquitin-proteasome pathway under normal conditions. ER stress conditions enhanced the stability of BBF2H7 and OASIS, and promoted transcription of their target genes. HMG-CoA reductase degradation 1 (HRD1), an ER-resident E3 ubiquitin ligase, ubiquitinated BBF2H7 and OASIS under normal conditions, whereas ER stress conditions dissociated the interaction between HRD1 and BBF2H7 or OASIS. The stabilization of OASIS in Hrd1(-/-) cells enhanced the expression of collagen fibers during osteoblast differentiation, whereas a knockdown of OASIS in Hrd1(-/-) cells suppressed the production of collagen fibers. These findings suggest that ER stress stabilizes OASIS family members and this is a novel molecular mechanism for the activation of ER stress transducers. Cell Death and Differentiation (2012) 19, 1939-949; doi:10.1038/cdd.2012.77; published online 15 June 2012

発表雑誌等の名称

CELL DEATH AND DIFFERENTIATION

出版者

NATURE PUBLISHING GROUP

19

12

開始ページ

1939

終了ページ

1949

発行又は発表の年月

2012-12

査読の有無

無し

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.1038/cdd.2012.77

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID