論文

基本情報

氏名 日野 真一郎
氏名(カナ) ヒノ シンイチロウ
氏名(英語) HINO SHINICHIROU
所属 中村学園大学 栄養科学部 栄養科学科
職名 教授

題名

A novel ER stress transducer, OASIS, expressed in astrocytes

単著・共著の別

 

著者

Atsushi Saito
Shin-Ichiro Hino
Tomohiko Murakami
Shinichi Kondo
Kazunori Imaizumi

担当区分

 

概要

Secretory and transmembrane proteins are correctly folded or processed in the endoplasmic reticulum (ER). Various stresses disturb ER function and provoke the accumulation of unfolded proteins in the ER lumen. This condition is termed ER stress. Recently, ER stress has been linked to neuronal death in various neurodegenerative diseases. Among the cell populations in the nervous system, which comprises heterogeneous cell types including neuronal and glial cells, astrocytes have the unique ability of being able to tolerate and even proliferate under ischemic and hypoxic conditions that lead to ER stress. This review introduces a novel ER stress transducer, old astrocyte specifically induced substance (OASIS), that regulates the signaling of the un-folded protein response specifically in astrocytes and contributes to resistance to ER stress. In addition, current information is summarized regarding new types of ER stress transducers homologous to OASIS that are involved in cell type-specific ER stress responses.

発表雑誌等の名称

ANTIOXIDANTS & REDOX SIGNALING

出版者

MARY ANN LIEBERT, INC

9

5

開始ページ

563

終了ページ

571

発行又は発表の年月

2007-05

査読の有無

無し

招待の有無

無し

記述言語

英語

掲載種別

 

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.1089/ars.2006.1520

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID