論文

基本情報

氏名 日野 真一郎
氏名(カナ) ヒノ シンイチロウ
氏名(英語) HINO SHINICHIROU
所属 中村学園大学 栄養科学部 栄養科学科
職名 教授

題名

Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis

単著・共著の別

 

著者

Shin-ichiro Hino
Shinichi Kondo
Kazuya Yoshinaga
Atsushi Saito
Tomohiko Murakami
Soshi Kanemoto
Hiroshi Sekiya
Kazuyasu Chihara
Yuji Aikawa
Hideaki Hara
Takashi Kudo
Tomohisa Sekimoto
Taro Funamoto
Etsuo Chosa
Kazunori Imaizumi

担当区分

 

概要

Endoplasmic reticulum (ER) stress response is important for protein maturation in the ER. Some murine models for bone diseases have provided significant insight into the possibility that pathogenesis of osteoporosis is related to ER stress response of osteoblasts. We examined a possible correlation between osteoporosis and ER stress response. Bone specimens from 8 osteoporosis patients and 8 disease-controls were used for immunohistochemical analysis. We found that ER molecular chaperones, such as BiP (immunoglobulin heavy-chain binding protein) and PDI (protein-disulfide isomerase) are down-regulated in osteoblasts from osteoporosis patients. Based on this result, we hypothesized that up-regulation of ER molecular chaperones in osteoblasts could restore decreased bone formation in osteoporosis. Therefore, we investigated whether treatment of murine model for osteoporosis with BIX (BiP inducer X), selective inducer BiP, could prevent bone loss. We found that oral administration of BIX effectively improves decline in bone formation through the activation of folding and secretion of bone matrix proteins. Considering these results together, BIX may be a potential therapeutic agent for the prevention of bone loss in osteoporosis patients.

発表雑誌等の名称

JOURNAL OF BONE AND MINERAL METABOLISM

出版者

SPRINGER TOKYO

28

2

開始ページ

131

終了ページ

138

発行又は発表の年月

2010-03

査読の有無

無し

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

10.1007/s00774-009-0117-z

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

形式

無償ダウンロード

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID